General description

Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the organs rather than thyroid^1-2, germ cell tumors³, and malignant mesothelioma.^4-5 It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.⁶ TTF-1 labeling is also seen in thyroid and thyroid-derived tumors.⁷ TTF-1 immunostaining is useful in the differentiation between pulmonary and nonpulmonary origin of adenocarcinomas in malignant effusions.⁸ TTF-1 staining is very reliable in discerning whether a brain metastasis has arisen from a pulmonary or nonpulmonary site, particularly when dealing with adenocarcinomas and large-cell carcinomas.⁹

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

TTF-1 Positive Control Slides, Product No. 343S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality